Working Group 3-Pathophysiological roles of ALDO/MR in cardiovascular diseases

Key outcomes will be to better understand the consequences of MR activation in the cardiovascular system and their therapeutic and clinical implications, as well as the underlying mechanism of MR activation in the CV system.

The WG3 will study the pathological consequences of the activation and the modulation of the Aldo/MR system on the function and structure in the cardiovascular system, with a special focus on its participation in the development of complications of different cardiovascular risk factors. Such risk factors include hypertension, obesity, atherosclerosis, ageing and heart failure. WG3 will combine complementary and synergistic expertise of partners who have made major contributions to the understanding of Aldosterone action and MR activation in cardiovascular pathophysiology.

The main objectives of the WG3 will be the following:

  1. To investigate the potential mechanisms and the consequences of Aldo/MR activation in conditions leading to endothelial dysfunction, vascular inflammation and remodeling/calcification in the context of hypertension, atherosclerosis, obesity, heart or renal failure.
  2. To define the electrophysiological impact of MR activation in cardiomyocytes and its consequences for arrhythmia generation
  3. To analyze the mechanisms by which the Aldo/MR system influences vascular stiffening and hypercoagulable phenotypes in arterial ageing, hypertension, and heart failure.
  4. To identify new biotargets involved in Aldo/MR-induced cardiovascular remodeling associated with hypertension, obesity and heart failure development. These newly identified Aldo/MR targets could be additional therapeutic targets to modulate Aldo/MR effects in cardiovascular remodeling.
  5. To examine the implication of Aldo/MR system in the regulation of the coronary reserve and its impact on myocardial infarct
  6. To explore the role of inflammation in the cardiovascular consequences of MR activation.
Working Group 3 members

Natalia López Andrés, Spain. WG Leader

Rhian Touyz, UK

Kristina Kusche-Vihrog, Germany

Tilman Volk, Germany

Victoria Cachofeiro, Spain

Ana Briones, Spain

Antoine Ouvrard-Pascaud, France

Frederic Jaisser, France

Jean-Pierre Benitah, France

Patrick Lacolley, France

Luis Michea, Chile

Stefan Chłopicki, Poland

Konstantinos Kallaras, Greece

Aristeidis Kritis, Greece

Michael Wagner, Germany

Research Group 1

N Lopez Andres

Head: Dr Natalia López-Andrés, Head, Cardiovascular Translational Research group and WG3 Leader

Navarrabiomed, Miguel Servet Foundation.

Complejo Hospitalario de Navarra, Pamplona, Spain

Keywords: Aldosterone damage, myocardium, cardiac valves, biomarkers Galectin-3 & ST-2.

Click here for more information on Dr López-Andrés

 

Research Group 2

Heaa briones cropd: Dr. Ana Briones. Ramon y Cajal contract (PhD).

Universidad Autónoma de Madrid group. Spain

Keywords: Cardiovascular pathologies,role of renin-angiotensin-aldosterone system,oxidative stress, COX-2

Click here for more information on Dr Briones’ research

Research Group 3

Frederic JAISSERHead: Professor Frederic Jaisser MD, PhD

Head of  Department,  Integrative Physiology and Pathophysiology,Cordeliers Research Centre, INSERM

Keywords: Mineralocorticoid receptor, angiotensin II,novel target tissues, Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Click here for more information on Prof. Jaisser’s research

 

Research Group 4

S ChlopickiHead: Professor Stefan Chłopicki  M.D., Ph.D

Head, Department of Experimental Pharmacology, Jagiellonian Centre for Experimental Therapeutics,

Jagiellion University, Kracow, Poland

Keywords: Endothelial dysfunction and targeted therapy, cardiovascular, new targets for liver steatosis,

 Secondary WG: WG5

Click here for more information on Prof Chlopicki’s research

Research Group 5

l micheaHead: Professor Luis Michea MD PhD,

Faculty of Medicine, University of Chile

Keywords: Hypertension, kidney damage, inflammation in chronic kidney disease

Click here for more information on Prof Michea’s research

 

Research Group 6:

v cachofeiroHead: Prof Victoria Cachofeiro, Cardiovascular and metabolic research group

Universidad Complutense, Physiology and Internal Medicine Departments

School of Medicine, Madrid ,Spain

Keywords: Cardiovascular disease, obesity, diabetes, aldosterone

Click here to find out more about Prof Cachfeiro’s research

Research Group 7:

kusche vihrogHead: Dr Kristina Kusche-Vihrog, Institute of Physiology II, Medical Faculty, University of Münster, Germany

Keywords: Epithelial Sodium Channle (ENaC), Epithelial cell plasticity

Click here to find out more about Dr Kusche-Vihrog’s research