Working Group 5-Pathophysiological roles of ALDO/MR in novel target tissues

Key outcomes will be to characterize the novel roles for aldosterone and MR activation in these non-classical tissue targets as well as to identify potentially new therapeutic indications prone to MR antagonism.

A new exciting area of MR biology began with the identification of MR expression in different target tissues, such as lung airway epithelia , eyes and skin, brain, cardiomyocytes, vasculature, macrophages/monocytes, erythrocytes and adipose tissue. This particular distribution of MR in such a wide range of tissues has suggested novel and unexpected roles for MR under different physiological and pathophysiological contexts, ranging from metabolic syndrome and oxidative stress to choroid retinopathy and stress adaptability.

The goal of WG5 is to gain deeper insights in the pathophysiological roles of MR activation in “non classical” targets of aldosterone, focusing particularly on adipose tissue, brain, eye (choroid vessels) and blood cells (leukocytes and erythrocytes). WP5 has 3 main aims:

  1. Understand the pathophysiological role of aldosterone and MR in ‘non-classical targets” and their potential implications in disease states. Interactions with the other WGs will be essential to achieve this goal since an integrated approach will be required. For example, consequences of hyperaldosteronism on these targets, interactions between these novel targets and the cardiovascular or renal systems or the role of the microvasculature will be important to be analyzed.
  2. Identify new signaling pathways of MR in novel target tissues, taking advantage of different
  3. expertise and animal models available in the COST network, which should accelerate scientific progress in each research group.
  4. Facilitating the exchange of researchers (senior scientists and students) to promote the sharing of different expertise in different scientific areas, from neuroscience, metabolism, fish biology, oxidative stress and inflammation. This should help the acquisition of diverse scientific approaches, potentially revealing novel unexpected applications in each research settings.
  5. Propose novel potential applications of MR antagonists in diverse clinical settings, where the use of MR blockers or modulators has not yet been explored. This will favor translational and clinical studies in WG6

Working Group 5 members

Massimiliano Caprio, WG Leader, Italy

Decio Armanini, Italy

Francine-Behar Cohen, France

Ron de Kloet, The Netherlands

Patrick Prunet, France

Francesco Fallo, Italy

Pernille B. Lærkegaard Hansen, Denmark

Nourdine Faresse, Switzerland

Research Group 1

M CaprioHead: Prof. Massimiliano Caprio MD, PhD, IRCCS San Raffaele Pisana – Research Center, Laboratory of Cardiovascular Endocrinology, Rome, Italy

Keywords: Mineralocorticoid receptor,adipose tissue, vascular endothelium, Intercellular Adhesion Molecule 1 (ICAM-1)

Click here for more information on Dr Caprio’s research

Research Group 2

R de KloetHead: Professor Edo Ronald de Kloet, Faculty of Science, Leiden/Amsterdam Center for Drug Research, Medical Pharmacology, University of Leiden, Amsterdam, the Netherlands

Keywords: Stress-related brain disorders, corticosteroid hormone, adrenal

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Research Group 3

P Laerkegaard HansenHead: Pernille Bjørg Lærkegaard HansenPhD, MSc, Professor, Cardiovascular and Renal Research
Institute for Medical BiologyJ.B. Winsløws Vej 21, 3. sal , 5000 Odense C, Denmark

Phone: +45 65503717

Fax: +45 6613 3479

Email: pbhansen@health.sdu.dk

Homepage: Pernille B. Lærkegaard Hansen

Keywords: 

  • Aldosterone, vascular and renal effects studied in human tissue and transgenic mice.
  • Role of non-L-type calcium channels for blood pressure regulation and kidney function studied in human and mice

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Research Group 4

F FALLO-cropHead: Prof Francesco Fallo, Associate Professor of Medicine, Department of Medicine of the University of Padova, Italy

Keywords: Adrenal steroid production, primary aldosteronism, aldosterone and MR activation in adipose tissue

Website: http://www.medicinadimed.unipd.it

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Paloma Perez

Research Group 5

Head: Paloma Pérez, Dept. of Pathology and Cell and Molecular Therapy, Instituto de Biomedicina de Valencia (IBV-CSIC), Spain

Keywords: Glucocorticoid receptor, Mineralocorticoid receptor, cutaneous biology, inflammation

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Research Group 6

Head: Ozlen Konu, Associate Professor, Bilkent University, Department of Molecular Biology and Genetics, 06800 Ankara Turkey

Keywords: RNAi/overexpression of receptors, nicotine, aldosterone, estrogen and anticancer drugs.

Click here for more information on Dr Konu’s research