Pathophysiological roles of ALDO/MR in cardiovascular diseases

Working Group 3

Key outcomes will be to better understand the consequences of MR activation in the cardiovascular system and their therapeutic and clinical implications, as well as the underlying mechanism of MR activation in the CV system.

The WG3 will study the pathological consequences of the activation and the modulation of the Aldo/MR system on the function and structure in the cardiovascular system, with a special focus on its participation in the development of complications of different cardiovascular risk factors. Such risk factors include hypertension, obesity, atherosclerosis, ageing and heart failure. WG3 will combine complementary and synergistic expertise of partners who have made major contributions to the understanding of Aldosterone action and MR activation in cardiovascular pathophysiology.

The main objectives of the WG3 will be the following:

  •     To investigate the potential mechanisms and the consequences of Aldo/MR activation in conditions leading to endothelial dysfunction, vascular inflammation and remodeling/calcification in the context of hypertension, atherosclerosis, obesity, heart or renal failure.
  •     To define the electrophysiological impact of MR activation in cardiomyocytes and its consequences for arrhythmia generation
  •     To analyze the mechanisms by which the Aldo/MR system influences vascular stiffening and hypercoagulable phenotypes in arterial ageing, hypertension, and heart failure.
  •     To identify new biotargets involved in Aldo/MR-induced cardiovascular remodeling associated with hypertension, obesity and heart failure development. These newly identified Aldo/MR targets could be additional therapeutic targets to modulate Aldo/MR effects in cardiovascular remodeling.
  •     To examine the implication of Aldo/MR system in the regulation of the coronary reserve and its impact on myocardial infarct
  •     To explore the role of inflammation in the cardiovascular consequences of MR activation.

Working Group 3 members

  • Natalia López Andrés, Spain. WG Leader
  • Rhian Touyz, UK
  • Kristina Kusche-Vihrog, Germany
  • Tilman Volk, Germany
  • Victoria Cachofeiro, Spain
  • Ana Briones, Spain
  • Antoine Ouvrard-Pascaud, France
  • Frederic Jaisser, France
  • Jean-Pierre Benitah, France
  • Patrick Lacolley, France
  • Luis Michea, Chile
  • Stefan Chłopicki, Poland
  • Konstantinos Kallaras, Greece
  • Aristeidis Kritis, Greece
  • Michael Wagner, Germany

 

N Lopez AndresResearch Group 1
Head: Dr Natalia López-Andrés, Head, Cardiovascular Translational Research group and WG3 Leader
Navarrabiomed, Miguel Servet Foundation.
Complejo Hospitalario de Navarra, Pamplona, Spain
Keywords: Aldosterone damage, myocardium, cardiac valves, biomarkers Galectin-3 & ST-2.
Click here for more information on Dr López-Andrés


a briones cropResearch Group 2
Head: Dr. Ana Briones. Ramon y Cajal contract (PhD).
Universidad Autónoma de Madrid group. Spain
Keywords: Cardiovascular pathologies,role of renin-angiotensin-aldosterone system,oxidative stress, COX-2
Click here for more information on Dr Briones’ research


Frederic JAISSERResearch Group 3
Head: Professor Frederic Jaisser MD, PhD
Head of  Department,  Integrative Physiology and Pathophysiology,Cordeliers Research Centre, INSERM
Keywords: Mineralocorticoid receptor, angiotensin II,novel target tissues, Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Click here for more information on Prof. Jaisser’s research


S ChlopickiResearch Group 4
Head: Professor Stefan Chłopicki  M.D., Ph.D
Head, Department of Experimental Pharmacology, Jagiellonian Centre for Experimental Therapeutics,
Jagiellion University, Kracow, Poland
Keywords: Endothelial dysfunction and targeted therapy, cardiovascular, new targets for liver steatosis,
Secondary WG: WG5
Click here for more information on Prof Chlopicki’s research


l micheaResearch Group 5
Head: Professor Luis Michea MD PhD,
Faculty of Medicine, University of Chile
Keywords: Hypertension, kidney damage, inflammation in chronic kidney disease
Click here for more information on Prof Michea’s research


v cachofeiroResearch Group 6:
Head: Prof Victoria Cachofeiro, Cardiovascular and metabolic research group
Universidad Complutense, Physiology and Internal Medicine Departments
School of Medicine, Madrid ,Spain
Keywords: Cardiovascular disease, obesity, diabetes, aldosterone
Click here to find out more about Prof Cachfeiro’s research


kusche vihrogResearch Group 7:
Head: Dr Kristina Kusche-Vihrog, Institute of Physiology II, Medical Faculty, University of Münster, Germany
Keywords: Epithelial Sodium Channle (ENaC), Epithelial cell plasticity
Click here to find out more about Dr Kusche-Vihrog’s research

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